Crumrine, David
Emeritus Professor
Education
- A.B., 1966, Ashland College
- Ph.D., 1971, University of Wisconsin, Madison
- Postdoctoral, 1971-72, Massachusetts Institute of Technology/Georgia Tech.
- Visiting Scholar Institute of Molecular Science, 1980 Okazaki, Japan.
- Visiting Scholar, 1981, Oxford University.
- Visiting Lecturer, Summer 1988, University of Chicago
Research Interests
Using methylene blue dye derivatives, as singlet oxygen generators, attached to peptides and proteins continues to be interesting. Initial work on neuropeptides showed efficient singlet oxygen production and good binding. Calcitonin was also attached and studied. We are now working with cross-linked hemoglobins aiming toward a selective new technique for photodynamic therapy.
Collaborative work on gramicidin dimers has been very productive! Working with a physiologist and a theoretician, we have begun to better understanding ion transport in this novel peptide system. We are synthesizing a new series of dimers to expand our work.
All of this can be viewed as mechanistic studies. We also work on remote effects on addition reactions and the use of 33S 17O, 23Na, and 6Li NMR to probe solvation, pKa, substituent, and counterion effects in sulfonate acids, salts, and buffers. 33S and 17O NMR are sensitive to pH effects. A substituent changes the state of protonation in aromatic sulfonic acids and various buffers such as HEPES.
Publications/Research Listings
"" J.J. Feigenbaum, M.D.Choubal, D.S. Crumrine, and J.R. Kanofsky, Peptides, 1996, 17, 1213-1217.
"", J.J. Feigenbaum, M.D. Choubal, D.S. Crumrine, J.R. Kanofsky, K. Payza, Peptides, 1996, 17,1279-1284.
"", S. Cukierman, E. P. Quigley, and D. S. Crumrine. Biophys. J., 1997, 73, 2489-2502.
"Long range aryl migration and electrocyclic ring opening (LRAMERO)", M. Peeran and D.S. Crumrine, Trends in Organic Chemistry, 1997, 6, 45-53.
"", E. P. Quigley, A. J. Emerick, D. S. Crumrine, and S. Cukierman. Biophys. J., 1998, 75, 2811-2820.
"", E.P.Quigley, P. Quigley, D.S. Crumrine, and S. Cukierman, Biophys. J., 1999, 77, 2479-2491.
"" E. P. Quigley, D. S. Crumrine and S. Cukierman, J. Memb. Bio., 2000, 174, 207-212.
"" K. M. Armstrong, E. P. Quigley, D. S. Crumrine, S. Cukierman, Biophys. J., 2001, 80, 1810-1818.
"" S. Narayan, D.L. Wyatt, D.S. Crumrine, S. Cukierman, Biophys. J., 2007, 93, 1571-1579.